1. Predictors based on TCR sequences only

1.1 Machine learning approaches

TEMPO

Liu et al. BioRxiv 2025

Executable

MixTCRpred

Croce et al. Nat Comm 2024

Executable

ERGO-II

Springer et al. Front Immunol 2021

Webserver

Executable

NetTCR

Jensen et al. eLife 2024

Webserver

Executable

TULIP

Meynard-Piganeau et al. PNAS 2024

Executable

EPIC-TRACE

Korpela et al. Bioinformatics 2023

Executable

TITAN

Weber et al. Bioinformatics 2021

Executable

STAPLER

Kwee et al. BioRxiv 2024

Executable

ImRex

Moris et al. Brief Bioinfo 2020

Executable

1.2 Distance-based approaches

TCRdist3

Mayer-Blackwell et al. eLife 2022

Executable

TCRbase

Montemurro et al. Front Immunol 2022

Executable

GLIPH2

Huang et al. Nat Biotech 2020

Webserver

SwarmTCR

Ehrlich et al. BMC Bioinformatics 2021

Executable

2. Predictors integrating 3D models of TCR-epitope complexes

TCRDock

Bradley eLife 2023

Executable

NetTCR-struc

Deleuran et al. Front Immunol 2025

Executable

TCRen

Karnaukhov et al. Nature Comp Science 2024

Executable

DeepAIR

Zhao et al. Science Advances 2023

Executable

TCRBridge

Messemaker et al. BioRxiv 2025

Executable